Acth, Cortisone and Allied Subjects

The place of cortisone and corticotrophin in the treatment of certain acute phases of leprosy.

THE PLACE OF CORTISONE AND CORTICOTROPHIN IN THE TREATMENT OF CERTAIN ACUTE PHASES OF LEPROSY W. H. JOPLING, M.R.C.P. (LOND. & EDIN.), D.T.M. & H. R. G. COCHRANE , M.D., F.R.C.P., D.T.M. & H. In 1936 a steroid was isolated from the adrenal cortex 1 which became known as compound E, and in 1949 its name was changed to cortisone. It is converted in the body into a closely allied substance, hydroc...

Effect of cortisone and certain other steroids on the peripheral vasculature in arthritis.

The frequent occurrence of a defective peripheral circulation in rheumatoid arthritis has now been well established since the early observations of Pemberton (1923). Moreover, many of the therapeutic measures employed in this and allied conditions result in an increased peripheral blood flow. After intramuscular injections of adrenocorticotropic hormone (ACTH) changes in the blood flow in the k...

Hemodynamic changes associated with fluid retention induced in noncardiac subjects by corticotropin (ACTH) and cortisone; comparison with the hemodynamic changes of congestive heart failure.

Effects of exogenous adrenocorticotropic hormone (ACTH) upon pituitary ACTH concentration after prolonged cortisone treatment and stress.

Symptoms and metabolic abnormalities closely resembling those of hypoadrenalism have been reported following cessation of prolonged treatment with adrenal steroids (1-5). Sudden death following surgery has been reported in association with this syndrome and has been ascribed to failure of the hypothalamic-pituitary-adrenal system to respond to stress (6-9). Since prolonged administration of cor...

The reversibility of certain rheumatic and nonrheumatic conditions by the use of cortisone or of the pituitary adrenocotropic hormone.

It may be appropriate to discuss in this Nobel Lecture three general aspects of cortisone and pituitary adrenocorticotropic hormone (ACTH): (1) the development of the theory which eventually led to the use of cortisone and ACTH in rheumat ic and cer ta in o ther condi t ions ; th i s I sha l l do in some detail, giving certain data not published heretofore; (2) the present status of cortisone a...